SARS coronavirus 3b accessory protein modulates transcriptional activity of RUNX1b.
Identifieur interne : 001C65 ( Main/Exploration ); précédent : 001C64; suivant : 001C66SARS coronavirus 3b accessory protein modulates transcriptional activity of RUNX1b.
Auteurs : Bhavna Varshney [Inde] ; Sudhakar Agnihothram ; Sudhakar Agnihotram ; Yee-Joo Tan ; Ralph Baric ; Sunil K. LalSource :
- PloS one [ 1932-6203 ] ; 2012.
Descripteurs français
- KwdFr :
- ARN messager (génétique), ARN messager (métabolisme), Activation de la transcription (génétique), Activation enzymatique, Animaux, Chimiokine CCL3 (génétique), Chimiokine CCL3 (métabolisme), Extracellular Signal-Regulated MAP Kinases (métabolisme), Humains, Interleukine-2 (génétique), Liaison aux protéines, Lignée cellulaire, Noyau de la cellule (métabolisme), Phosphorylation, Protéines virales non structurales (métabolisme), Protéines virales régulatrices ou accessoires (métabolisme), Régions promotrices (génétique) (génétique), Sites de fixation, Souris, Sous-unité alpha 2 du facteur CBF (génétique), Sous-unité alpha 2 du facteur CBF (métabolisme), Transcription génétique, Virus du SRAS (métabolisme).
- MESH :
- génétique : ARN messager, Activation de la transcription, Chimiokine CCL3, Interleukine-2, Régions promotrices (génétique), Sous-unité alpha 2 du facteur CBF.
- métabolisme : ARN messager, Chimiokine CCL3, Extracellular Signal-Regulated MAP Kinases, Noyau de la cellule, Protéines virales non structurales, Protéines virales régulatrices ou accessoires, Sous-unité alpha 2 du facteur CBF, Virus du SRAS.
- Activation enzymatique, Animaux, Humains, Liaison aux protéines, Lignée cellulaire, Phosphorylation, Sites de fixation, Souris, Transcription génétique.
English descriptors
- KwdEn :
- Animals, Binding Sites, Cell Line, Cell Nucleus (metabolism), Chemokine CCL3 (genetics), Chemokine CCL3 (metabolism), Core Binding Factor Alpha 2 Subunit (genetics), Core Binding Factor Alpha 2 Subunit (metabolism), Enzyme Activation, Extracellular Signal-Regulated MAP Kinases (metabolism), Humans, Interleukin-2 (genetics), Mice, Phosphorylation, Promoter Regions, Genetic (genetics), Protein Binding, RNA, Messenger (genetics), RNA, Messenger (metabolism), SARS Virus (metabolism), Transcription, Genetic, Transcriptional Activation (genetics), Viral Nonstructural Proteins (metabolism), Viral Regulatory and Accessory Proteins (metabolism).
- MESH :
- chemical , genetics : Chemokine CCL3, Core Binding Factor Alpha 2 Subunit, Interleukin-2, RNA, Messenger.
- genetics : Promoter Regions, Genetic, Transcriptional Activation.
- metabolism : Cell Nucleus, Chemokine CCL3, Core Binding Factor Alpha 2 Subunit, Extracellular Signal-Regulated MAP Kinases, RNA, Messenger, SARS Virus, Viral Nonstructural Proteins, Viral Regulatory and Accessory Proteins.
- Animals, Binding Sites, Cell Line, Enzyme Activation, Humans, Mice, Phosphorylation, Protein Binding, Transcription, Genetic.
Abstract
The causative agent of severe acute respiratory syndrome, SARS coronavirus (SARS-CoV) genome encodes several unique group specific accessory proteins with unknown functions. Among them, accessory protein 3b (also known as ORF4) was lately identified as one of the viral interferon antagonist. Recently our lab uncovered a new role for 3b in upregulation of AP-1 transcriptional activity and its downstream genes. Thus, we believe that 3b might play an important role in SARS-CoV pathogenesis and therefore is of considerable interest. The current study aims at identifying novel host cellular interactors of the 3b protein.
DOI: 10.1371/journal.pone.0029542
PubMed: 22253733
Affiliations:
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Le document en format XML
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Lal</name></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Binding Sites</term><term>Cell Line</term><term>Cell Nucleus (metabolism)</term><term>Chemokine CCL3 (genetics)</term><term>Chemokine CCL3 (metabolism)</term><term>Core Binding Factor Alpha 2 Subunit (genetics)</term><term>Core Binding Factor Alpha 2 Subunit (metabolism)</term><term>Enzyme Activation</term><term>Extracellular Signal-Regulated MAP Kinases (metabolism)</term><term>Humans</term><term>Interleukin-2 (genetics)</term><term>Mice</term><term>Phosphorylation</term><term>Promoter Regions, Genetic (genetics)</term><term>Protein Binding</term><term>RNA, Messenger (genetics)</term><term>RNA, Messenger (metabolism)</term><term>SARS Virus (metabolism)</term><term>Transcription, Genetic</term><term>Transcriptional Activation (genetics)</term><term>Viral Nonstructural Proteins (metabolism)</term><term>Viral Regulatory and Accessory Proteins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN messager (génétique)</term><term>ARN messager (métabolisme)</term><term>Activation de la transcription (génétique)</term><term>Activation enzymatique</term><term>Animaux</term><term>Chimiokine CCL3 (génétique)</term><term>Chimiokine CCL3 (métabolisme)</term><term>Extracellular Signal-Regulated MAP Kinases (métabolisme)</term><term>Humains</term><term>Interleukine-2 (génétique)</term><term>Liaison aux protéines</term><term>Lignée cellulaire</term><term>Noyau de la cellule (métabolisme)</term><term>Phosphorylation</term><term>Protéines virales non structurales (métabolisme)</term><term>Protéines virales régulatrices ou accessoires (métabolisme)</term><term>Régions promotrices (génétique) (génétique)</term><term>Sites de fixation</term><term>Souris</term><term>Sous-unité alpha 2 du facteur CBF (génétique)</term><term>Sous-unité alpha 2 du facteur CBF (métabolisme)</term><term>Transcription génétique</term><term>Virus du SRAS (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Chemokine CCL3</term><term>Core Binding Factor Alpha 2 Subunit</term><term>Interleukin-2</term><term>RNA, Messenger</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Promoter Regions, Genetic</term><term>Transcriptional Activation</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN messager</term><term>Activation de la transcription</term><term>Chimiokine CCL3</term><term>Interleukine-2</term><term>Régions promotrices (génétique)</term><term>Sous-unité alpha 2 du facteur CBF</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cell Nucleus</term><term>Chemokine CCL3</term><term>Core Binding Factor Alpha 2 Subunit</term><term>Extracellular Signal-Regulated MAP Kinases</term><term>RNA, Messenger</term><term>SARS Virus</term><term>Viral Nonstructural Proteins</term><term>Viral Regulatory and Accessory Proteins</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ARN messager</term><term>Chimiokine CCL3</term><term>Extracellular Signal-Regulated MAP Kinases</term><term>Noyau de la cellule</term><term>Protéines virales non structurales</term><term>Protéines virales régulatrices ou accessoires</term><term>Sous-unité alpha 2 du facteur CBF</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Binding Sites</term><term>Cell Line</term><term>Enzyme Activation</term><term>Humans</term><term>Mice</term><term>Phosphorylation</term><term>Protein Binding</term><term>Transcription, Genetic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activation enzymatique</term><term>Animaux</term><term>Humains</term><term>Liaison aux protéines</term><term>Lignée cellulaire</term><term>Phosphorylation</term><term>Sites de fixation</term><term>Souris</term><term>Transcription génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The causative agent of severe acute respiratory syndrome, SARS coronavirus (SARS-CoV) genome encodes several unique group specific accessory proteins with unknown functions. Among them, accessory protein 3b (also known as ORF4) was lately identified as one of the viral interferon antagonist. Recently our lab uncovered a new role for 3b in upregulation of AP-1 transcriptional activity and its downstream genes. Thus, we believe that 3b might play an important role in SARS-CoV pathogenesis and therefore is of considerable interest. The current study aims at identifying novel host cellular interactors of the 3b protein.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><noCountry><name sortKey="Agnihothram, Sudhakar" sort="Agnihothram, Sudhakar" uniqKey="Agnihothram S" first="Sudhakar" last="Agnihothram">Sudhakar Agnihothram</name><name sortKey="Agnihotram, Sudhakar" sort="Agnihotram, Sudhakar" uniqKey="Agnihotram S" first="Sudhakar" last="Agnihotram">Sudhakar Agnihotram</name><name sortKey="Baric, Ralph" sort="Baric, Ralph" uniqKey="Baric R" first="Ralph" last="Baric">Ralph Baric</name><name sortKey="Lal, Sunil K" sort="Lal, Sunil K" uniqKey="Lal S" first="Sunil K" last="Lal">Sunil K. Lal</name><name sortKey="Tan, Yee Joo" sort="Tan, Yee Joo" uniqKey="Tan Y" first="Yee-Joo" last="Tan">Yee-Joo Tan</name></noCountry><country name="Inde"><noRegion><name sortKey="Varshney, Bhavna" sort="Varshney, Bhavna" uniqKey="Varshney B" first="Bhavna" last="Varshney">Bhavna Varshney</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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